Author

S. Crotta

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 5 Assay:bulk RNA-seq· 4 Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Wack· 5 shared A. Ohnemus· 2 shared D. Schnepf· 2 shared M. Llorian· 2 shared A. Ambrosi· 1 shared A. Bottazzi· 1 shared A. Breithaupt· 1 shared A. Broggi· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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5 shared papersImmunology

A. Wack

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Impaired immune response drives age-dependent severity of COVID-19

J. Beer, S. Crotta, A. Breithaupt, A. Ohnemus, J. Becker, B. Sachs, L. Kern, M. Llorian, N. Ebert, F. Labroussaa, T. T. N. Tran, B. S. Trueeb, J. Jores, V. Thiel, M. Beer, , D. Schnepf

This study identifies impaired interferon responses as a cause of age-dependent COVID-19 severity and shows that combined IFN-γ and IFN-λ therapy can mitigate disease in aged mice.

bioRxiv · Apr 21, 2022Immunology

Hypoxia inducible factors regulate infectious SARS-CoV-2, epithelial damage and respiratory symptoms in a hamster COVID-19 model.

P. A. Wing, M. Prange-Barczynska, A. Cross, S. Crotta, C. Orbegozo Rubio, X. Cheng, J. M. Harris, X. Zhuang, R. L. Johnson, K. A. Ryan, Y. Hall, M. W. Carroll, F. Issa, P. Balfe, A. Wack, , J. A. McKeating

This study shows that activating HIF signaling reduces SARS-CoV-2 infection and respiratory symptoms in hamsters by decreasing viral RNA and epithelial damage.

bioRxiv · Mar 15, 2022Microbiology

Severity of SARS-CoV-2 infection as a function of the interferon landscape across the respiratory tract of COVID-19 patients.

B. Sposito, A. Broggi, L. Pandolfi, S. Crotta, R. Ferrarese, S. Sisti, N. Clementi, A. Ambrosi, E. Liu, V. Frangipane, L. Saracino, L. Marongiu, F. Facchini, A. Bottazzi, T. Fossali, , I. Zanoni

This study examines IFN-I and IFN-III expression patterns in the respiratory tract of COVID-19 patients, finding higher IFN-III levels in severe cases and varying roles across anatomical sites.

bioRxiv · Mar 30, 2021 · PreprintImmunology

Rotavirus susceptibility of antibiotic-treated mice ascribed to diminished expression of interleukin-22

D. Schnepf, P. Hernandez, T. Mahlakoiv, S. Crotta, M. E. Sullender, S. T. Peterson, A. Ohnemus, C. Michiels, I. Gentle, L. Dumoutier, C. A. Reis, A. Diefenbach, A. Wack, M. T. Baldridge, P. Staeheli

This study shows that antibiotic-treated mice are more susceptible to rotavirus due to reduced IL-22 expression, which normally inhibits viral replication through mechanisms independent of IFN signaling.

bioRxiv · Feb 18, 2021Immunology

Type I and III interferons disrupt lung epithelial repair during recovery from viral infection

J. Major, S. Crotta, M. Llorian, T. M. McCabe, H. H. Gad, R. Hartmann, A. Wack

This study shows that type I and III interferons impair lung epithelial repair during viral infection recovery, increasing disease severity and bacterial susceptibility.

bioRxiv · May 5, 2020Immunology