Author

M. T. Baldridge

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Immunology· 3

Signature Assays, Organisms & Methods

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Organism:mouse· 8 Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 7 Assay:bulk RNA-seq· 4 Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Research Focus:gene regulatory network inference· 2 Assay:proteomics· 2

Frequent Co-Authors

E. A. Kennedy· 4 shared F. C. Walker· 2 shared H. Ingle· 2 shared H. Makimaa· 2 shared L. L. Hsieh· 2 shared R. C. Orchard· 2 shared R. Rodgers· 2 shared S. Aggarwal· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersMicrobiology

E. A. Kennedy

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Interferons and tuft cell numbers are bottlenecks for persistent murine norovirus infection

S. Aggarwal, F. C. Walker, J. S. Weagley, B. T. McCune, X. Wu, L. Schreifer, H. Makimaa, D. Lawrence, P. Sridhar, M. T. Baldridge

This study uses barcoded viruses to show that IFN-λ and tuft cell numbers limit persistent murine norovirus infection, with distinct viral populations in intestinal and extraintestinal sites.

bioRxiv · Feb 22, 2024Microbiology

Sequential early-life viral infections modulate the microbiota and adaptive immune responses to systemic and mucosal vaccination

Y. Li, J. M. Molleston, A. H. Kim, H. Ingle, S. Aggarwal, L. Nolan, A. Hassan, L. Foster, M. Diamond, M. T. Baldridge

This study shows that sequential early-life viral infections in mice reduce antibody responses to SARS-CoV-2 vaccination while altering immune cell profiles and gut microbiota.

bioRxiv · Aug 31, 2023Microbiology

Microbiota produced indole metabolites disrupt host cell mitochondrial energy production and inhibit Cryptosporidium parvum growth

L. Funkhouser-Jones, R. Xu, G. Wilke, Y. Fu, L. A. Shriefer, H. Makimaa, R. Rodgers, E. A. Kennedy, K. VanDussen, T. Stappenbeck, M. T. Baldridge, L. D. Sibley

The paper identifies indole metabolites from the microbiota that inhibit Cryptosporidium parvum growth by disrupting host mitochondrial function and parasite mitosome membrane potential.

bioRxiv · May 25, 2023 · PreprintMicrobiology

Genetic mapping reveals Pou2af2-dependent tuning of tuft cell differentiation and intestinal type 2 immunity

M. S. Nadjsombati, N. Niepoth, L. M. Webeck, E. A. Kennedy, D. L. Jones, M. T. Baldridge, A. Bendesky, J. von Moltke

The paper identifies Pou2af2 isoform usage as a regulator of tuft cell differentiation and intestinal type 2 immunity through genetic mapping in mice.

bioRxiv · Oct 19, 2022 · PreprintImmunology

A homeostatic interferon-lambda response to bacterial microbiota stimulates preemptive antiviral defense within discrete pockets of intestinal epithelium

J. A. Van Winkle, S. T. Peterson, E. A. Kennedy, M. J. Wheadon, H. Ingle, C. Desai, R. Rodgers, D. A. Constant, A. P. Wright, L. Li, M. Artyomov, S. Lee, M. T. Baldridge, T. J. Nice

The paper shows bacterial microbiota induce localized IFN-lambda-driven antiviral defenses in intestinal epithelial cells, enhancing host resistance to enteric viruses.

bioRxiv · Jun 2, 2021Immunology

Rotavirus susceptibility of antibiotic-treated mice ascribed to diminished expression of interleukin-22

D. Schnepf, P. Hernandez, T. Mahlakoiv, S. Crotta, M. E. Sullender, S. T. Peterson, A. Ohnemus, C. Michiels, I. Gentle, L. Dumoutier, C. A. Reis, A. Diefenbach, A. Wack, M. T. Baldridge, P. Staeheli

This study shows that antibiotic-treated mice are more susceptible to rotavirus due to reduced IL-22 expression, which normally inhibits viral replication through mechanisms independent of IFN signaling.

bioRxiv · Feb 18, 2021Immunology

CD300lf conditional knockout mouse reveals strain-specific cellular tropism for murine norovirus

V. R. Graziano, M. M. Alfajaro, C. Schmitz, R. B. Filler, M. S. Strine, J. Wei, L. L. Hsieh, M. T. Baldridge, T. J. Nice, S. Lee, R. C. Orchard, C. B. Wilen

This study uses a Cd300lf conditional knockout mouse to show that CD300lf on tuft cells is essential for persistent MNoVCR6 infection, while myelomonocytic cells are major targets for non-persistent MNoVCW3, with STAT1 restricting its tropism.

bioRxiv · Aug 19, 2020Microbiology

CD300lf is the primary physiologic receptor of murine norovirus but not human norovirus

V. Graziano, F. C. Walker, E. A. Kennedy, J. Wei, K. Ettayebi, M. Simoes, R. Filler, E. Hassan, L. L. Hsieh, A. O. Kolawole, C. Wobus, L. C. Lindesmith, R. S. Baric, M. Estes, R. C. Orchard, , C. Wilen

This paper identifies CD300lf as the primary receptor for murine norovirus in vivo but shows it is not used by human norovirus.

PLOS Pathogens · Apr 6, 2020Peer-reviewedMicrobiology