Author

I. Hafner-Bratkovic

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Assay:protein sequence· 1 Assay:proteomics· 1

Frequent Co-Authors

C. L. Evavold· 2 shared J. C. Kagan· 2 shared B. Correia· 1 shared D. Hacker· 1 shared D. Lainscek· 1 shared D. Peterhoff· 1 shared E. Borsic· 1 shared E. M. Ngwa· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersImmunology

C. L. Evavold

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3 papers

Recent·Most cited

The pore-forming protein gasdermin D is a cellular redox sensor

P. Devant, E. Borsic, E. M. Ngwa, J. R. Thiagarajah, I. Hafner-Bratkovic, C. L. Evavold, J. C. Kagan

This study shows that reactive oxygen species (ROS) oxidize gasdermin D (GSDMD), promoting its assembly into a pore-forming complex and enhancing pyroptosis.

bioRxiv · Mar 11, 2022 · PreprintImmunology

Downstream of gasdermin D cleavage, a Ragulator-Rag-mTORC1 pathway promotes pore formation and pyroptosis

C. L. Evavold, I. Hafner-Bratkovic, J. C. Kagan

This study identifies the Ragulator-Rag-mTORC1 pathway as essential for pore formation and pyroptosis after GSDMD cleavage.

bioRxiv · Nov 2, 2020Immunology

Immune response to vaccine candidates based on different types of nanoscaffolded RBD domain of the SARS-CoV-2 spike protein

D. Lainscek, T. Fink, V. Forstneric, I. Hafner-Bratkovic, S. Orehek, Z. Strmsek, M. Mancek Keber, P. Pecan, H. Esih, S. Malensek, J. Aupic, P. Dekleva, T. Plaper, S. Vidmar, L. Kadunc, , R. Jerala

This study evaluates DNA vaccines with RBD domains scaffolded by different peptides, finding that the β-annulus scaffold elicits the strongest immune response in mice.

bioRxiv · Aug 28, 2020 · PreprintImmunology