Author

J. C. Kagan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 7 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 5 Organism:human· 5 Assay:proteomics· 5 Research Focus:cell signaling & trafficking· 4 Research Focus:cell type annotation· 3 Organism:mouse· 3 Approach:biophysical modeling· 1

Frequent Co-Authors

C. L. Evavold· 3 shared P. Devant· 3 shared I. Hafner-Bratkovic· 2 shared A. A. Govande· 1 shared A. Banerjee· 1 shared A. C. Magalhaes· 1 shared A. Cao· 1 shared A. Gouveia· 1 shared

Activity by Year

2020-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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3 shared papersImmunology

C. L. Evavold

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

ROS-dependent palmitoylation is an obligate licensing modification for GSDMD pore formation

G. Du, L. B. Healy, L. David, C. Walker, P. Fontana, Y. Dong, P. Devant, R. Puthenveetil, S. B. Ficarro, A. Banerjee, J. C. Kagan, J. Lieberman, H. Wu

This study identifies palmitoylation as a required modification for GSDMD pore formation, showing that ROS induces this modification and is essential for membrane translocation and cell death.

bioRxiv · Mar 7, 2023Immunology

Correction of age-associated defects in dendritic cell functions enables CD4+ T cells to eradicate tumors in the elderly

D. Zhivaki, F. Borriello, S. Kennedy, C. L. Evavold, K. M. Bahleda, K. L. Chapman, I. Zanoni, J. C. Kagan

This study shows that CD4+ T cells, supported by hyperactivator-stimulated dendritic cells, can eliminate tumors in elderly mice, suggesting a strategy to correct age-related immune defects.

bioRxiv · Nov 8, 2022 · PreprintImmunology

Phagosome-mediated activation of STING during diverse bacterial infections

S. A. Ragland, J. C. Kagan

The paper shows that bacterial cyclic dinucleotides activate STING via phagocytosis, regardless of bacterial virulence or species.

bioRxiv · Oct 28, 2022 · PreprintImmunology

The pore-forming protein gasdermin D is a cellular redox sensor

P. Devant, E. Borsic, E. M. Ngwa, J. R. Thiagarajah, I. Hafner-Bratkovic, C. L. Evavold, J. C. Kagan

This study shows that reactive oxygen species (ROS) oxidize gasdermin D (GSDMD), promoting its assembly into a pore-forming complex and enhancing pyroptosis.

bioRxiv · Mar 11, 2022 · PreprintImmunology

Three functionally distinct classes of cGAS proteins in nature revealed by self-DNA-induced interferon responses

K. Mosallanejad, W. Zhou, A. A. Govande, D. Hancks, P. J. Kranzusch, J. C. Kagan

The paper identifies three functional classes of cGAS proteins in mammals based on their self-DNA reactivity and interferon response mechanisms.

bioRxiv · Mar 9, 2022Immunology

Human cytomegalovirus vMIA inhibits MAVS oligomerization at peroxisomes in an MFF-dependent manner

A. R. Ferreira, A. Gouveia, A. C. Magalhaes, I. Valenca, M. Marques, J. C. Kagan, D. Ribeiro

This study shows that HCMV's vMIA inhibits MAVS oligomerization at peroxisomes via an MFF-dependent mechanism, distinct from its mitochondrial antiviral interference.

bioRxiv · Feb 25, 2022Cell Biology

Evolution-inspired dissection of caspase activities enables the redesign of caspase-4 into an LPS sensing interleukin-1 converting enzyme

P. Devant, A. Cao, J. C. Kagan

The paper redesigns human caspase-4 to function as a single-protein LPS sensing pathway for IL-1β cleavage, inspired by carnivore caspases, and shows cat caspase-4 exhibits similar activity.

bioRxiv · Dec 7, 2020Immunology

Downstream of gasdermin D cleavage, a Ragulator-Rag-mTORC1 pathway promotes pore formation and pyroptosis

C. L. Evavold, I. Hafner-Bratkovic, J. C. Kagan

This study identifies the Ragulator-Rag-mTORC1 pathway as essential for pore formation and pyroptosis after GSDMD cleavage.

bioRxiv · Nov 2, 2020Immunology