Author

C. L. Evavold

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Assay:flow cytometry· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

J. C. Kagan· 3 shared I. Hafner-Bratkovic· 2 shared D. Zhivaki· 1 shared E. Borsic· 1 shared E. M. Ngwa· 1 shared F. Borriello· 1 shared I. Zanoni· 1 shared J. R. Thiagarajah· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersImmunology

J. C. Kagan

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Correction of age-associated defects in dendritic cell functions enables CD4+ T cells to eradicate tumors in the elderly

D. Zhivaki, F. Borriello, S. Kennedy, C. L. Evavold, K. M. Bahleda, K. L. Chapman, I. Zanoni, J. C. Kagan

This study shows that CD4+ T cells, supported by hyperactivator-stimulated dendritic cells, can eliminate tumors in elderly mice, suggesting a strategy to correct age-related immune defects.

bioRxiv · Nov 8, 2022 · PreprintImmunology

The pore-forming protein gasdermin D is a cellular redox sensor

P. Devant, E. Borsic, E. M. Ngwa, J. R. Thiagarajah, I. Hafner-Bratkovic, C. L. Evavold, J. C. Kagan

This study shows that reactive oxygen species (ROS) oxidize gasdermin D (GSDMD), promoting its assembly into a pore-forming complex and enhancing pyroptosis.

bioRxiv · Mar 11, 2022 · PreprintImmunology

Downstream of gasdermin D cleavage, a Ragulator-Rag-mTORC1 pathway promotes pore formation and pyroptosis

C. L. Evavold, I. Hafner-Bratkovic, J. C. Kagan

This study identifies the Ragulator-Rag-mTORC1 pathway as essential for pore formation and pyroptosis after GSDMD cleavage.

bioRxiv · Nov 2, 2020Immunology