A Multi-pronged Screening Approach Targeting Inhibition of ETV6 PNT Domain Polymerization
C. A. N. Gerak, S. M. Zhang, A. D. Balgi, I. J. Sadowski, R. B. Sessions, L. P. McIntosh, M. Roberge
This study develops experimental and computational assays to identify small molecule inhibitors of ETV6 PNT domain polymerization, finding no direct binders but gaining insights for future therapeutic development.
bioRxiv · Aug 20, 2020Biochemistry