Thiopurines activate an antiviral unfolded protein response that blocks viral glycoprotein accumulation in cell culture infection model
P. D. Slaine, M. Kleer, B. Duguay, E. S. Pringle, E. Kadijk, S. Ying, A. D. Balgi, M. Roberge, C. McCormick, D. A. Khaperskyy
This study shows that thiopurines 6-TG and 6-TGo activate the UPR to block viral glycoprotein accumulation in cell culture models of influenza and coronavirus infections.
bioRxiv · Sep 30, 2020Microbiology