Author

I. Lewis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Organism:chicken / avian· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. H. M. van Vliet· 1 shared B. Sanz-Bernardo· 1 shared H. Munyanduki· 1 shared H. Ramay· 1 shared I. R. Haga· 1 shared J. Hope· 1 shared J. Stagg· 1 shared K. Brown· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperImmunology

A. H. M. van Vliet

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

mt-LAF3 is a pseudouridine synthase ortholog required for mitochondrial rRNA and mRNA gene expression in Trypanosoma brucei

S. McDermott, V. Pham, I. Lewis, M. Tracy, K. Stuart

This study shows that mt-LAF3 is essential for mitochondrial rRNA and mRNA expression in T. brucei but lacks PUS catalytic activity, instead functioning as an RNA-stabilizing scaffold.

bioRxiv · Feb 23, 2023 · PreprintMicrobiology

The immune response to lumpy skin disease virus in cattle is influenced by inoculation route

P. C. Fay, N. Wijesiriwardana, H. Munyanduki, B. Sanz-Bernardo, I. Lewis, I. R. Haga, K. Moffat, A. H. M. van Vliet, J. Hope, S. Graham, P. Beard

This study compares immune responses in cattle inoculated with LSDV via needle or arthropod vectors, finding differences in clinical disease development and immune markers like IgM and IFN-γ.

bioRxiv · Sep 22, 2022Immunology

Immunotherapy efficacy in colorectal cancer is dependent on activation of a microbial-metabolite-immune circuit

L. Mager, R. Burkhard, N. Cooke, K. Brown, H. Ramay, S. Paik, J. Stagg, R. Grooves, M. Gallo, I. Lewis, M. Geuking, K. McCoy

This study identifies specific gut bacteria and the metabolite inosine that enhance immunotherapy efficacy in colorectal cancer by promoting Th1 cell activation through the adenosine A2A receptor.

bioRxiv · Feb 26, 2020 · PreprintCancer Biology