Senescent cells cluster CTCF on nuclear speckles to sustain their splicing program
S. Palikyras, V. Varamogianni-Mamatsi, Y. Zhu, S. Ramasamy, A. Mizi, I. Liebermann, A. Stavropoulou, I. Papadionysiou, D. Bartsch, Y. Kargapolova, K. Sofiadis, C. Nikolaou, L. Kurian, M. Oudelaar, M. Barbieri, A. Papantonis
This paper identifies senescence-induced CTCF clusters (SICCs) and shows they sustain the senescence splicing program by repurposing nuclear speckle components.
bioRxiv · Jul 16, 2024 · PreprintCell Biology