M. Barbieri

Senescent cells cluster CTCF on nuclear speckles to sustain their splicing program

This paper identifies senescence-induced CTCF clusters (SICCs) and shows they sustain the senescence splicing program by repurposing nuclear speckle components.

Genotypic identification of polyclonal plasma cells in plasma cell dyscrasias shows an aberrant single-cell phenotype with clinical implications

The paper identifies polyclonal plasma cells in plasma cell dyscrasias using single-cell RNAseq and shows their pro-inflammatory status and clinical relevance through a derived signature.

Simultaneous assessment of mechanical and electrical function in Langendorff-perfused ex-vivo mouse heart

This paper develops a modified Langendorff setup to simultaneously record electrical and mechanical function in isolated mouse hearts, revealing electro-mechanical interactions during bigeminy and ischemia-reperfusion.

Competition between transcription and loop extrusion modulates promoter and enhancer dynamics

The paper investigates how transcription and loop extrusion interact to influence promoter and enhancer dynamics through live tracking and simulations.

Relationship between Deceleration Morphology and Phase Rectified Signal Averaging-based Parameters during Labor

This study examines differences in fetal heart rate deceleration morphology between normoxic and hypoxic sheep fetuses during umbilical cord occlusions and shows that PRSA-based parameters correlate with these morphological changes.

High-resolution structural and functional deep brain imaging using adaptive optics three-photon microscopy

This paper develops a method for high-resolution deep brain imaging in mice using adaptive optics three-photon microscopy and demonstrates its ability to image deep cortical structures and astrocyte calcium transients.