S. Ramasamy

Comparative analysis of serological assays and sero-surveillance for SARS-CoV-2 exposure in US cattle

This study evaluates serological assays for SARS-CoV-2 in US cattle, finding no evidence of natural infection or transmission and highlighting issues with false positives in neutralization assays.

A SARS-CoV-2 vaccine designed for manufacturability results in unexpected potency and non-waning humoral response

This paper describes a SARS-CoV-2 vaccine, MT-001, that provides durable, broad, and potent immunity without waning or requiring boosting.

In Vitro Validation of Computationally Predicted Oncogenic Driver Mutations in EGFR Tyrosine Kinase Domain

This study predicts and validates two EGFR mutations as potential oncogenic drivers using in vitro experiments and machine learning.

A CNN model for predicting binding affinity changes between SARS-CoV-2 spike RBD variants and ACE2 homologues

The paper introduces a CNN model to predict RBD-hACE2 binding affinity changes for SARS-CoV-2 variants, achieving high accuracy and identifying variants with improved binding affinity.

Comprehensive analysis of disease pathology in immunocompetent and immunocompromised hamster models of SARS-CoV-2 infection

This study compares SARS-CoV-2 infection outcomes in immunocompetent and immunocompromised hamsters, finding that histopathological changes better predict disease severity than viral load or antibody levels.

A Simple Ultrafast Multicolor Immunolabelling and Clearing Approach for Whole-Organ and Large Tissue 3D Imaging

The paper introduces SUMIC, a fast and simple method for whole-organ and large tissue 3D imaging, revealing age-related expansion of lymphatic vessels in endocrine tissues.

Expanding AHL Acylases Horizon - Insights From Structural Analysis of Choloylglycine Hydrolases From Shewanella lohica PV-4

This paper identifies SlCGH1 from Shewanella loihica PV-4 as a novel AHL acylase with unique structural and functional properties distinct from known CGHs and AHL acylases.

Dissection of Catalytic Site in Crucial Gut Microbiome Enzyme: Bile Salt Hydrolase

The paper investigates the mechanistic details of EfBSH activity through structural and electrostatic analyses of mutants, identifying key interactions affecting catalytic activity and allostery.

Baicalein suppresses Tau fibrillization by sequestering oligomers

This study investigates Baicalein's ability to inhibit Tau aggregation and dissolve preformed oligomers and fibrils, suggesting its potential as a therapeutic for Alzheimer's disease.

Murburn concept explains the acutely lethal effect of cyanide

This study compares two mechanisms of cyanide toxicity, concluding that the murburn concept better explains its acutely lethal effect on cellular respiration.