The Endoplasmic Reticulum pool of Bcl-xL dampens the Unfolded Protein Response through IP3R-dependent Calcium Release
L. Jabbour, T. Nguyen, R. Gadet, O. Lohez, I. Mikaelian, P. Gonzalo, T. Luyten, M. Chalabi, G. Bultynck, R. Rimokh, G. Gillet, N. Popgeorgiev
This study shows that Bcl-xL at the endoplasmic reticulum (ER) dampens the unfolded protein response (UPR) by reducing IP3R-mediated calcium release, thereby preventing ER calcium depletion and cell death.
bioRxiv · Jan 27, 2021 · PreprintCell Biology