I. P. Witte

Site-specific lipidation enhances IFITM3 membrane interactions and antiviral activity

This study shows site-specific S-palmitoylation of IFITM3 enhances its membrane interactions and antiviral activity by modulating its conformation and lipid membrane binding.

CRISPR-Cas12a exploits R-loop asymmetry to form double strand breaks

This study shows that Cas12a uses R-loop asymmetry to cut the second DNA strand without direct protein interaction, explaining its double-strand break mechanism.