Author

R. Wiewiora

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

W. Sherman· 2 shared Y. Li· 2 shared A. Dickson· 1 shared A. Evdokimov· 1 shared A. M. Razavi· 1 shared A. Percher· 1 shared A. Vinitsky· 1 shared B. Mostofian· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiophysics

W. Sherman

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Author profile →

3 papers

Recent·Most cited

STORMM: Structure and TOpology Replica Molecular Mechanics for chemical simulations

D. S. Cerutti, S. Boothroyd, R. Wiewiora, W. Sherman

STORMM is a high-performance molecular simulation engine optimized for CPUs and GPUs, offering improved throughput and accuracy for small molecule and protein simulations.

bioRxiv · Mar 27, 2024 · PreprintBiophysics

Atomic-Resolution Prediction of Degrader-mediated Ternary Complex Structures by Combining Molecular Simulations with Hydrogen Deuterium Exchange

T. Dixon, D. MacPherson, B. Mostofian, T. Dauzhenka, S. Lotz, D. McGee, S. Shechter, U. Shrestha, R. Wiewiora, Z. A. McDargh, F. Pei, R. Pal, J. V. Ribeiro, T. Wilkerson, V. Sachdeva, , J. A. Izaguirre

This paper predicts atomic-resolution structures of degrader-mediated ternary complexes using combined HDX-MS and molecular dynamics simulations, validated by experimental data.

bioRxiv · Sep 26, 2021 · PreprintBiophysics

Site-specific lipidation enhances IFITM3 membrane interactions and antiviral activity

E. H. Garst, H. Lee, T. Das, S. Bhattacharya, A. Percher, R. Wiewiora, I. P. Witte, Y. Li, M. Goger, T. Peng, W. Im, H. C. Hang

This study shows site-specific S-palmitoylation of IFITM3 enhances its membrane interactions and antiviral activity by modulating its conformation and lipid membrane binding.

bioRxiv · Sep 11, 2020Biochemistry