Author

J. C. Cofsky

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:host-pathogen & immune response· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

J. A. Doudna· 3 shared G. J. Knott· 2 shared C. J. Huang· 1 shared C. L. Gee· 1 shared D. Karandur· 1 shared E. Nogales· 1 shared I. P. Witte· 1 shared J. Kuriyan· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 18 mutual co-author links

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3 shared papersBiochemistry

J. A. Doudna

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Author profile →

3 papers

Recent·Most cited

Crystal structure of an RNA/DNA strand exchange junction

J. C. Cofsky, G. J. Knott, C. L. Gee, J. A. Doudna

The paper reports the X-ray crystal structure of an RNA/DNA strand exchange junction, revealing structural principles of A-to-B helical transitions in RNA/DNA hybrids.

bioRxiv · Jan 24, 2022Biochemistry

CRISPR-Cas9 bends and twists DNA to read its sequence

J. C. Cofsky, K. M. Soczek, G. J. Knott, E. Nogales, J. A. Doudna

This paper reveals how CRISPR-Cas9 bends and twists DNA to flip nucleotides toward guide RNA for sequence interrogation.

bioRxiv · Sep 6, 2021Biochemistry

CRISPR-Cas12a exploits R-loop asymmetry to form double strand breaks

J. C. Cofsky, D. Karandur, C. J. Huang, I. P. Witte, J. Kuriyan, J. A. Doudna

This study shows that Cas12a uses R-loop asymmetry to cut the second DNA strand without direct protein interaction, explaining its double-strand break mechanism.

bioRxiv · Feb 10, 2020Biochemistry