Author

I. Powley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

L. Officer-Jones· 3 shared C. Nixon· 2 shared D. Strathdee· 2 shared J. Le Quesne· 2 shared R. Pennie· 2 shared S. B. Coffelt· 2 shared A. D. Campbell· 1 shared A. Kaur· 1 shared

Activity by Year

2023-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersCancer Biology

L. Officer-Jones

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

eIF4A1 is essential for reprogramming the translational landscape of Wnt-driven colorectal cancers

J. A. Waldron, G. Kanellos, R. C. L. Smith, J. R. P. Knight, J. Munro, C. Alexandrou, N. Vlahov, L. Pardo-Fernandez, M. Moore, S. L. Gillen, D. Strathdee, D. Stevenson, F. C. Warrander, K. Gilroy, C. Nixon, , O. J. Sansom

This study shows eIF4A1 is critical for supporting translational demands in Wnt-driven colorectal cancers, while eIF4A2 loss accelerates tumourigenesis, and eFT226 inhibits eIF4A1 function in these models.

bioRxiv · Nov 10, 2023 · PreprintCancer Biology

ERBB signalling contributes to immune evasion in KRAS-driven lung adenocarcinoma

S. Laing, B. Kruspig, R. Shaw, L. Officer-Jones, S. Edwards, D. McKinven, Y.-C. Hsieh, I. Powley, N. Brady, R. Pennie, R. Kwan, A. Lima, S. Myrta, M. Periyasamy, I. C. Dye, , D. J. Murphy

The paper investigates how ERBB signaling contributes to immune evasion in KRAS-driven lung adenocarcinoma using a novel mouse model and finds that transient ERBB blockade can restore immune surveillance when combined with PD1 blockade.

bioRxiv · Jul 24, 2023 · PreprintCancer Biology

A protein hydroxylase couples epithelial membrane biology to nucleolar ribosome biogenesis

E. Hendrix, R. Andrijes, U. Boora, A. Kaur, J. R. Bundred, L. Officer-Jones, r. pennie, I. Powley, A. Zayer, R. Heilig, C. A. E. Westrip, S. F. Fletcher, C. D. Eaton, T. J. Kennedy, S. Piasecka, , M. L. Coleman

This study identifies a novel role for MINA in coupling epithelial membrane integrity to nucleolar ribosome biogenesis through its interaction with MPP6.

bioRxiv · Mar 15, 2023 · PreprintCell Biology