Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
9 papers
Recent·Most cited
I. Dye, S. Laing, I. Garner, H. B. Mirza, N. Iyer, N. Brady, P. Spiliopoulou, S. Spear, J. Robinson, F. Fiorentino, M. J. Fuchter, D. J. Murphy, I. J. McNeish, R. Brown
This study shows that inhibiting H3K27/H3K9 methylation maintenance reverses cMYC-mediated immune repression in cancer, improving survival in mouse models.
bioRxiv · Oct 18, 2023 · PreprintCancer Biology
N. D. Vincelette, X. Yu, A. T. Kuykendall, J. Moon, S. Su, C.-H. Cheng, R. Sammut, T. N. Razabdouski, H. V. Nguyen, E. A. Eksioglu, O. Chan, N. Al Ali, P. C. Patel, D. H. Lee, S. Nakanishi, , S. Yun
This study identifies a MYC-S100A9 axis driving triple negative myelofibrosis and shows it is a therapeutic target.
bioRxiv · Sep 25, 2023Cancer Biology
X. L. Raffo-Iraolagoitia, A. J. McFarlane, B. Kruspig, F. Fercoq, J. Secklehner, M. De Donatis, J. B. G. Mackey, R. Wiesheu, S. Laing, Y.-C. Hsieh, R. Shaw, R. Corbyn, C. Nixon, C. Miller, K. Kirschner, , L. M. Carlin
The paper identifies that CD27+ γδ T cells impair the differentiation of tumor-associated macrophages into airway macrophages in lung adenocarcinoma.
bioRxiv · Sep 14, 2023Immunology
S. Laing, B. Kruspig, R. Shaw, L. Officer-Jones, S. Edwards, D. McKinven, Y.-C. Hsieh, I. Powley, N. Brady, R. Pennie, R. Kwan, A. Lima, S. Myrta, M. Periyasamy, I. C. Dye, , D. J. Murphy
The paper investigates how ERBB signaling contributes to immune evasion in KRAS-driven lung adenocarcinoma using a novel mouse model and finds that transient ERBB blockade can restore immune surveillance when combined with PD1 blockade.
bioRxiv · Jul 24, 2023 · PreprintCancer Biology
J. J. Ringelberg, E. J. M. Koenen, B. Sauter, A. Aebli, J. G. Rando, J. R. Iganci, L. P. de Queiroz, D. J. Murphy, M. Gaudeul, A. Bruneau, M. Luckow, G. P. Lewis, J. T. Miller, M. F. Simon, L. S. B. Jordao, , C. E. Hughes
The paper shows that precipitation gradients drive phylogenetic turnover in Mimosoid legumes across tropical regions, with 95% of speciation occurring within a precipitation niche.
bioRxiv · May 27, 2022Evolutionary Biology
J. B. G. Mackey, A. J. McFarlane, T. Jamieson, R. Jackstadt, X. L. Raffo-Iraolagoitia, J. Secklehner, X. Cortes-Lavaud, F. Fercoq, W. Clarke, A. Hedley, K. Gilroy, S. Lilla, J. Vuononvirta, G. J. Graham, K. De Filippo, , L. M. Carlin
This study identifies Ly6G expression levels as a marker for neutrophil maturation stages and shows spleen-derived neutrophils mature faster with distinct transcriptional profiles.
bioRxiv · Jul 21, 2021 · PreprintImmunology
A. Blomme, C. Peter, E. Mui, G. Rodriguez Blanco, L. M. Mason, L. E. Jamieson, G. H. McGregor, S. Lilla, C. Ntala, R. Patel, M. Thiry, S. H. Kung, C. A. Ford, L. K. Rushworth, D. J. McGarry, , H. Y. Leung
This study identifies THEM6 as a marker of ADT resistance in prostate cancer, showing its role in lipid homeostasis and stress response, and highlights it as a potential therapeutic target.
bioRxiv · Apr 4, 2021Cancer Biology
O. Gericke, R. M. Fowler, A. M. Heskes, M. Bayly, S. J. Semple, C. P. Ndi, D. Staerk, C. J. Loland, D. J. Murphy, B. J. Buirchell, B. L. Moller
The paper investigates metabolite diversity in the plant genus Eremophila using phylogenetic and computational metabolomics tools to explore chemical and evolutionary relationships across 291 specimens.
bioRxiv · Nov 2, 2020Plant Biology
P. Farahmand, K. Gyuraszova, C. Rooney, X. L. Raffo-Iraolagoitia, E. Johnson, T. Chernova, T. Monteverde, K. Blyth, R. Duffin, L. M. Carlin, D. Lewis, J. Le Quesne, M. MacFarlane, D. J. Murphy
This study shows asbestos accelerates mesothelioma onset and increases tumor burden in a genetic mouse model, with increased macrophage infiltration, but macrophage suppression did not improve survival.
bioRxiv · Jun 16, 2020Cancer Biology