Author

J. Le Quesne

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cancer & tumor microenvironment· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 2

Frequent Co-Authors

C. Nixon· 2 shared I. Powley· 2 shared K. Blyth· 2 shared L. Officer-Jones· 2 shared A. D. Campbell· 1 shared A. Hemmes· 1 shared A. Katoch· 1 shared A. Kaur· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersCancer Biology

C. Nixon

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

eIF4A1 is essential for reprogramming the translational landscape of Wnt-driven colorectal cancers

J. A. Waldron, G. Kanellos, R. C. L. Smith, J. R. P. Knight, J. Munro, C. Alexandrou, N. Vlahov, L. Pardo-Fernandez, M. Moore, S. L. Gillen, D. Strathdee, D. Stevenson, F. C. Warrander, K. Gilroy, C. Nixon, , O. J. Sansom

This study shows eIF4A1 is critical for supporting translational demands in Wnt-driven colorectal cancers, while eIF4A2 loss accelerates tumourigenesis, and eFT226 inhibits eIF4A1 function in these models.

bioRxiv · Nov 10, 2023 · PreprintCancer Biology

A protein hydroxylase couples epithelial membrane biology to nucleolar ribosome biogenesis

E. Hendrix, R. Andrijes, U. Boora, A. Kaur, J. R. Bundred, L. Officer-Jones, r. pennie, I. Powley, A. Zayer, R. Heilig, C. A. E. Westrip, S. F. Fletcher, C. D. Eaton, T. J. Kennedy, S. Piasecka, , M. L. Coleman

This study identifies a novel role for MINA in coupling epithelial membrane integrity to nucleolar ribosome biogenesis through its interaction with MPP6.

bioRxiv · Mar 15, 2023 · PreprintCell Biology

Spatial regulation of the glycocalyx component Podocalyxin is a switch for pro-metastatic function

A. Roman-Fernandez, M. Mansour, F. G. Kugeratski, J. Anand, E. Sandilands, L. Galbraith, K. Rakovic, E. C. Freckmann, E. M. Cumming, J. Park, K. Nikolatou, S. Lilla, R. Shaw, D. Strachan, S. Mason, , D. M. Bryant

This study identifies PODXL as a decoy receptor for GAL3, revealing its role in promoting metastasis through integrin-based invasion and differential cortical targeting regulated by ubiquitination.

bioRxiv · Nov 4, 2022 · PreprintCell Biology

The role of SOX9 in non-small cell lung cancer progression is histopathology-selective.

E. W. Verschuren, J. Bao, K. Närhi, A. Teodosio, A. Hemmes, N. M. Linnavirta, M. I. Mäyränpää, K. Salmenkivi, J. Le Quesne

This study shows SOX9 has different roles in NSCLC progression depending on histopathology, promoting papillary adenocarcinoma but suppressing squamous metastasis.

bioRxiv · Nov 23, 2020 · PreprintCancer Biology

Asbestos accelerates disease onset in a genetic model of Malignant Pleural Mesothelioma

P. Farahmand, K. Gyuraszova, C. Rooney, X. L. Raffo-Iraolagoitia, E. Johnson, T. Chernova, T. Monteverde, K. Blyth, R. Duffin, L. M. Carlin, D. Lewis, J. Le Quesne, M. MacFarlane, D. J. Murphy

This study shows asbestos accelerates mesothelioma onset and increases tumor burden in a genetic mouse model, with increased macrophage infiltration, but macrophage suppression did not improve survival.

bioRxiv · Jun 16, 2020Cancer Biology

BCL11A interacts with SOX2 to control the expression of epigenetic regulators in lung squamous cell carcinoma

K. A. Lazarus, F. Hadi, E. Zambon, K. Bach, M.-F. Santolla, J. K. Watson, L. L. Correia, M. Das, R. Ugur, S. Pensa, L. Becker, L. S. Campos, G. Ladds, P. Liu, G. Evan, , W. T. Khaled

This study identifies BCL11A as an oncogene in lung squamous cell carcinoma, showing its interaction with SOX2 to regulate epigenetic factors and demonstrating potential therapeutic targets.

bioRxiv · Nov 22, 2017Cancer Biology