Cytomegalovirus-induced inactivation of TSC2 disrupts the coupling of fatty acid biosynthesis to glucose availability resulting in a vulnerability to glucose limitation
M. H. Raymonda, I. Rodriguez-Sanchez, X. Schafer, L. Smorodintsev-Schiller, I. S. Harris, J. Munger
This paper shows that HCMV's UL38 protein inactivates TSC2, disrupting glucose-fatty acid biosynthesis coupling and making cells vulnerable to glucose limitation.
bioRxiv · May 17, 2023 · PreprintMicrobiology