J. Munger

Bacteria-herpesvirus interaction reveals a proviral role of ISGylation in promoting herpesvirus capsid assembly

This study shows that ISGylation, induced by bacterial co-infection, promotes herpesvirus capsid assembly and replication by modifying viral proteins.

Raf1 promotes successful Human Cytomegalovirus replication and is regulated by AMPK-mediated phosphorylation during infection

This study shows that Raf1 promotes HCMV replication and is regulated by AMPK-mediated phosphorylation during infection, suggesting a therapeutic target for HCMV in immunocompromised patients.

FAM210A Regulates Mitochondrial Translation and Maintains Cardiac Mitochondrial Homeostasis

This study identifies FAM210A as a regulator of mitochondrial translation and cardiac mitochondrial homeostasis, showing its deficiency leads to heart failure and its overexpression rescues cardiac function in ischemic heart disease.

Cytomegalovirus-induced inactivation of TSC2 disrupts the coupling of fatty acid biosynthesis to glucose availability resulting in a vulnerability to glucose limitation

This paper shows that HCMV's UL38 protein inactivates TSC2, disrupting glucose-fatty acid biosynthesis coupling and making cells vulnerable to glucose limitation.

Glutathione supports lipid abundance in vivo

This study shows that glutathione (GSH) is essential for lipid abundance in adult tissues, particularly in the liver, by repressing NRF2.

TNFα-induced metabolic reprogramming drives an intrinsic anti-viral state

This study shows TNFα induces metabolic changes that enhance anti-viral defenses by promoting glycolysis and glycosylation of anti-viral proteins.

Human Cytomegalovirus induces neuronal enolase to support virally-mediated metabolicremodeling

This study identifies ENO2 as a key metabolic enzyme induced by HCMV to support glycolysis and UDP-sugar metabolism, essential for viral glycoprotein production and infectivity.

Pharmacologic profiling reveals lapatinib as a novel antiviral against SARS-CoV-2 in vitro

This study identifies lapatinib as a potent antiviral against SARS-CoV-2 in vitro, showing over 50,000-fold inhibition without toxicity.

Cardioprotection by nicotinamide mononucleotide (NMN): Involvement of glycolysis and acidic pH.

This study shows NMN protects hearts from ischemia-reperfusion injury by stimulating glycolysis and acidosis, with protection independent of SIRT1.

Potential Mechanisms Linking SIRT Activity And Hypoxic 2-Hydroxyglutarate Generation: No Role For Direct Enzyme (De)acetylation

This study investigates whether sirtuin-mediated acetylation regulates 2-HG production by metabolic enzymes, finding no direct link between enzyme acetylation and 2-HG generation.