Role of Lactate in the Regulation of Transcriptional Activity of Breast Cancer-Related Genes and Epithelial-to-Mesenchymal Transition Proteins: A Comparison of MCF7 and MDA-MB-231 Cancer Cell Lines
I. San-Millan, J. L. Martinez, S. L. Pickard, H. Yu, F. R. Hirsch, C. J. Rivard, G. A. Brooks
This study shows that endogenous lactate, not glucose, alters gene and protein expression in breast cancer cell lines, affecting carcinogenesis-related genes and EMT markers.
bioRxiv · Mar 23, 2023 · PreprintCancer Biology