K. C. Hansen

Biological and Genetic Determinants of Glycolysis: Phosphofructokinase Isoforms Boost Energy Status of Stored Red Blood Cells and Transfusion Outcomes

The paper identifies genetic polymorphisms and metabolite levels in stored red blood cells that correlate with hemolysis and transfusion outcomes.

Assessing Heterogeneity in the N-Telopeptides of Type I Collagen by Mass Spectrometry

The paper develops a method to identify N-terminal cross-linked peptides from collagen I in Achilles tendon using mass spectrometry, revealing differences in cross-links in bovine pulmonary hypertension.

ASSESSING TARGET SPECIFICITY OF THE SMALL MOLECULE INHIBITOR MARIMASTAT TO SNAKE VENOM TOXINS: A NOVEL APPLICATION OF THERMAL PROTEOME PROFILING

This study uses Thermal Proteome Profiling and PISA to assess marimastat's specificity against snake venom toxins, identifying its targets and interactions with specific proteoforms.

Trans-Omics analysis of post injury thrombo-inflammation identifies endotypes and trajectories in trauma patients.

Trans-omics analysis of longitudinal plasma samples from severely injured patients identifies endotypes and trajectories that predict clinical outcomes.

Metabolic Signatures of Performance in Elite World Tour Professional Cyclists

This study identifies metabolic signatures in elite cyclists during training and competition, revealing differences in metabolite profiles between exercise modes and race stages.

Myoscaffolds reveal laminin scarring is detrimental for stem cell function while sarcospan induces compensatory fibrosis

The paper develops a myoscaffold platform to study fibrotic ECM effects on stem cell function, finding that laminin scarring impairs SMPCs while sarcospan induces compensatory fibrosis.

Cardiac fibroblasts regulate cardiomyocyte hypertrophy through dynamic regulation of type I collagen

This study shows that type I collagen produced by cardiac fibroblasts regulates cardiomyocyte hypertrophy and fibrosis, with developmental and acute deletion effects on cardiac function.

Evaluation and refinement of sample preparation methods for extracellular matrix proteome coverage

The paper evaluates and refines sample preparation methods to improve ECM proteome coverage, achieving a 4-fold increase in unique ECM peptide identifications.

Injectable Myocardial Matrix Hydrogel Mitigates Negative Left Ventricular Remodeling in a Chronic Myocardial Infarction Model

This study investigates how a myocardial matrix hydrogel reduces negative left ventricular remodeling in chronic myocardial infarction by modulating immune response and gene expression.

Tissue specific muscle extracellular matrix hydrogel improves skeletal muscle regeneration in vivo over non-matched tissue source

This study shows that tissue-specific muscle ECM hydrogels enhance skeletal muscle regeneration in mice compared to non-matched tissue sources and saline.

Inflammation promotes tumor aggression by stimulating stromal cell-dependent collagen crosslinking and stromal stiffening

This study shows that inflammation promotes tumor aggression by stimulating stromal cell-dependent collagen crosslinking and stiffening, identifying lysyl hydroxylase two as a biomarker.

Targeting glutamine metabolism and redox state for leukemia therapy

This study shows that inhibiting glutaminase with CB-839 reduces glutathione and increases mitochondrial ROS in AML, leading to apoptosis, and that combining it with pro-oxidant drugs enhances cell death in AML and ALL.