Author

I. T. Mathews

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Approach:biophysical modeling· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

J. D. Watrous· 2 shared M. Jain· 2 shared Q. Ye· 2 shared R. K. Lau· 2 shared A. T. Whiteley· 1 shared B. Lowey· 1 shared C. S. Azimi· 1 shared J. J. Mekalanos· 1 shared

Activity by Year

2019-2019 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiochemistry

J. D. Watrous

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2 papers

Recent·Most cited

Structure and mechanism of a cyclic trinucleotide-activated bacterial endonuclease mediating bacteriophage immunity

R. K. Lau, Q. Ye, L. Patel, K. R. Berg, I. T. Mathews, J. D. Watrous, A. T. Whiteley, B. Lowey, J. J. Mekalanos, P. J. Kranzusch, M. Jain, K. Corbett

The paper characterizes NucC, a bacterial endonuclease activated by cyclic tri-AMP to mediate bacteriophage immunity through DNA cleavage or cell death.

bioRxiv · Jul 7, 2019Biochemistry

HORMA domain proteins and a Pch2-like ATPase regulate bacterial cGAS-like enzymes to mediate bacteriophage immunity

Q. Ye, R. K. Lau, I. T. Mathews, J. D. Watrous, C. S. Azimi, M. Jain, K. D. Corbett

The paper identifies a bacterial immunity pathway involving HORMA domain proteins, a cGAS-like enzyme, and a Pch2-like ATPase that mediates bacteriophage defense by generating a cyclic tri-AMP second messenger.

bioRxiv · Jul 6, 2019Biochemistry