Author

A. T. Whiteley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 5 Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Approach:biophysical modeling· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

Q. Ye· 3 shared H. E. Ledvina· 2 shared H. Zhou· 2 shared K. D. Corbett· 2 shared R. K. Lau· 2 shared A. M. Burroughs· 1 shared A. N. Conte· 1 shared B. Lowey· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersBiophysics

Q. Ye

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Bacterial antiviral defense pathways encode eukaryotic-like ubiquitination systems

L. R. Chambers, Q. Ye, J. Cai, M. Gong, H. E. Ledvina, H. Zhou, A. T. Whiteley, R. T. Suhandynata, K. D. Corbett

This study shows bacteria have a complete ubiquitination pathway similar to eukaryotes, with structural and functional parallels to eukaryotic systems.

bioRxiv · Sep 26, 2023 · PreprintBiophysics

Bacterial cGAS-like enzymes produce 2',3'-cGAMP to activate an ion channel that restricts phage replication

U. Tak, P. Walth, A. T. Whiteley

This study identifies bacterial CD-NTases that produce 2',3'-cGAMP to restrict phage replication by activating a chloride-selective ion channel.

bioRxiv · Jul 24, 2023Microbiology

Bacterial NLR-related proteins protect against phage

E. M. Kibby, A. N. Conte, A. M. Burroughs, T. A. Nagy, J. A. Vargas, L. Aravind, A. T. Whiteley

This study identifies bacterial NLR-related proteins that defend against phages, showing they share structural and functional features with eukaryotic NLRs and use a conserved signaling mechanism.

bioRxiv · Jul 19, 2022Microbiology

cGASylation by a bacterial E1-E2 fusion protein primes antiviral immune signaling

H. E. Ledvina, Q. Ye, Y. Gu, Y. Quan, R. K. Lau, H. Zhou, K. D. Corbett, A. T. Whiteley

The paper shows that a bacterial E1-E2 fusion protein, Cap2, primes cGAS for antiviral signaling through a process called cGASylation, which increases cGAMP production by ~50-fold.

bioRxiv · Mar 31, 2022Microbiology

Structure and mechanism of a cyclic trinucleotide-activated bacterial endonuclease mediating bacteriophage immunity

R. K. Lau, Q. Ye, L. Patel, K. R. Berg, I. T. Mathews, J. D. Watrous, A. T. Whiteley, B. Lowey, J. J. Mekalanos, P. J. Kranzusch, M. Jain, K. Corbett

The paper characterizes NucC, a bacterial endonuclease activated by cyclic tri-AMP to mediate bacteriophage immunity through DNA cleavage or cell death.

bioRxiv · Jul 7, 2019Biochemistry