Author

I. Tempera

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

D. Maestri· 3 shared L. B. Caruso· 3 shared A. Kossenkov· 2 shared S. Boyle· 2 shared A. Sobotka· 1 shared B. E. Gewurz· 1 shared B. Gewurz· 1 shared G. Napoletani· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersMicrobiology

D. Maestri

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The DNA loop release factor WAPL suppresses Epstein-Barr virus latent membrane protein expression to maintain the highly restricted latency I program

L. Murray-Nerger, D. Maestri, X. Liu, Z. Li, I. Tempera, M. Teng, B. E. Gewurz

This study shows that WAPL suppresses LMP1 and LMP2A expression in EBV latency I by altering DNA looping and histone marks, preventing the transition to latency II.

bioRxiv · May 9, 2024Microbiology

PARP1 Inhibition Halts EBV+ Lymphoma Progression by Disrupting the EBNA2/MYC Axis

G. Napoletani, S. S. Soldan, T. Kannan, S. Preston-Alp, P. Vogel, D. Maestri, L. B. Caruso, A. Kossenkov, A. Sobotka, P. M. Lieberman, I. Tempera

This study shows that PARP1 inhibition reduces EBV-driven lymphoma progression by disrupting the EBNA2/MYC axis in a mouse model.

bioRxiv · Jul 5, 2023 · PreprintCancer Biology

The Nuclear Lamina binds the EBV genome during latency and regulates viral gene expression

L. B. Caruso, R. Guo, K. Keith, J. Madzo, D. Maestri, S. Boyle, J. Wasserman, A. Kossenkov, B. Gewurz, I. Tempera

bioRxiv · Aug 5, 2021Microbiology

Epstein-Barr virus-encoded latent membrane protein 1 and B-cell growth transformation induces lipogenesis through fatty acid synthase.

M. Hulse, S. Johnson, S. Boyle, L. B. Caruso, I. Tempera

This paper shows that Epstein-Barr virus's LMP1 protein promotes B-cell transformation by inducing fatty acid synthesis and lipid droplet formation, suggesting lipogenesis inhibitors could treat LMP1-positive EBV-related cancers.

bioRxiv · Dec 15, 2019Microbiology