A. Kossenkov

Intraperitoneal activation of myeloid cells clears ascites and reveals IL27-dependent regression of metastatic ovarian cancer

The paper shows that intraperitoneal administration of β-glucan and IFNγ clears ascites and induces IL27-dependent tumor regression in metastatic ovarian cancer models.

Targeting LxCxE cleft pocket of retinoblastoma protein in M2 macrophages inhibits ovarian cancer progression

This study shows targeting the LxCxE cleft pocket of Rb in M2 macrophages inhibits ovarian cancer progression by reducing immunosuppressive TAMs and enhancing T cell infiltration.

Plasma Glycomic Markers of Accelerated Biological Aging During Chronic HIV Infection

This study identifies glycomic alterations in HIV-positive individuals that correlate with accelerated aging and comorbidities, suggesting potential biomarkers for early detection.

PARP1 Inhibition Halts EBV+ Lymphoma Progression by Disrupting the EBNA2/MYC Axis

This study shows that PARP1 inhibition reduces EBV-driven lymphoma progression by disrupting the EBNA2/MYC axis in a mouse model.

Age-related increases in fibroblasts-secreted IGFBP2 increase melanoma cell invasion and lipid synthesis.

This study shows that aged fibroblasts secrete more IGFBP2, which promotes melanoma cell invasion and lipid synthesis, and that neutralizing IGFBP2 reduces tumor growth and metastasis.

Perinuclear damage from nuclear envelope deterioration elicits stress responses that contribute to LMNA cardiomyopathy

This study identifies perinuclear stress responses from nuclear envelope deterioration as contributors to LMNA cardiomyopathy using a mouse model and translatome profiling.

Dasatinib Resensitizes MAPK Inhibitor Efficacy in Standard-of-Care Relapsed Melanomas

The paper identifies dasatinib as effective in restoring BRAFi/MEKi antitumor efficacy in 70% of resistant PDX models by targeting proteins involved in therapy escape.

The Nuclear Lamina binds the EBV genome during latency and regulates viral gene expression

Systematic Establishment of Robustness and Standards in Patient-Derived Xenograft Experiments and Analysis

The paper tests the reproducibility of PDX drug responses and sequence results across different labs using standardized protocols and workflows.

Vaccine-induced ICOS+CD38+ cTfh are sensitive biosensors of age-related changes in inflammatory pathways

The paper uses transcriptional profiling to show that vaccine-induced ICOS+CD38+ cTfh cells in elderly show inflammation-related gene signatures and age-associated biological changes.

IL-27 receptor signaling regulated stress myelopoiesis drives Abdominal Aortic Aneurysm development

This study shows that IL-27 receptor signaling in hematopoietic stem cells drives abdominal aortic aneurysm development by promoting myeloid cell accumulation.