PathologybioRxiv
Paclitaxel-induced peripheral neuropathy is caused by epidermal ROS and mitochondrial damage through conserved MMP-13 activation
A. M. Cirrincione, S. Rieger, A. D. Pellegrini…·J. Sagen
This study identifies epidermal ROS and mitochondrial damage as triggers of MMP-13 activation, leading to axon degeneration in paclitaxel-induced peripheral neuropathy.