Paclitaxel-induced peripheral neuropathy is caused by epidermal ROS and mitochondrial damage through conserved MMP-13 activation
A. M. Cirrincione, S. Rieger, A. D. Pellegrini, J. Dominy, M. E. Benjamin, I. Utkina-Sosunova, F. Lotti, S. Jergova, J. Sagen
This study identifies epidermal ROS and mitochondrial damage as triggers of MMP-13 activation, leading to axon degeneration in paclitaxel-induced peripheral neuropathy.
bioRxiv · Sep 5, 2019Pathology