Increased RNA and protein degradation is required for counteracting transcriptional burden and proteotoxic stress in human aneuploid cells
M. R. Ippolito, J. Zerbib, Y. Eliezer, E. Reuveni, S. Vigano', G. De Feudis, A. S. Kadmon, I. Vigorito, S. Martin, K. Laue, Y. Cohen-Sharir, S. Scorzoni, F. Vazquez, S. Santaguida, U. Ben-David
This study identifies increased RNA and protein degradation as mechanisms by which aneuploid cells counteract transcriptional burden and proteotoxic stress, revealing potential therapeutic targets.
bioRxiv · Jan 27, 2023Cancer Biology