Author

S. Scorzoni

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:genetic perturbation / CRISPR· 4 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. S. Kadmon· 2 shared E. Girardi· 2 shared E. Reuveni· 2 shared F. Vazquez· 2 shared G. De Feudis· 2 shared G. Superti-Furga· 2 shared J. Konecka· 2 shared J. Zerbib· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCancer Biology

A. S. Kadmon

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Human aneuploid cells depend on the RAF/MEK/ERK pathway for overcoming increased DNA damage

J. Zerbib, M. R. Ippolito, Y. Eliezer, G. De Feudis, E. Reuveni, A. S. Kadmon, S. Martin, S. Vigano', G. Leor, J. Berstler, K. Laue, Y. Cohen-Sharir, S. Scorzoni, F. Vazquez, U. Ben-David, S. Santaguida

This study identifies the RAF/MEK/ERK pathway as a critical dependency for aneuploid cells, showing increased pathway activity and sensitivity to its inhibition in aneuploid cancer cells.

bioRxiv · Jan 27, 2023Cancer Biology

Increased RNA and protein degradation is required for counteracting transcriptional burden and proteotoxic stress in human aneuploid cells

M. R. Ippolito, J. Zerbib, Y. Eliezer, E. Reuveni, S. Vigano', G. De Feudis, A. S. Kadmon, I. Vigorito, S. Martin, K. Laue, Y. Cohen-Sharir, S. Scorzoni, F. Vazquez, S. Santaguida, U. Ben-David

This study identifies increased RNA and protein degradation as mechanisms by which aneuploid cells counteract transcriptional burden and proteotoxic stress, revealing potential therapeutic targets.

bioRxiv · Jan 27, 2023Cancer Biology

Gain-of-function genetic screens in human cells identify SLC transporters overcoming environmental nutrient restrictions

M. Rebsamen, E. Girardi, V. Sedlyarov, K. Papakostas, J. Konecka, M. Vollert, S. Scorzoni, B. Guertl, K. Klavins, T. Wiedmer, G. Superti-Furga

This study uses gain-of-function genetic screens in human cells to identify SLC transporters that overcome nutrient limitations by enhancing uptake of essential amino acids.

bioRxiv · Apr 3, 2022Cell Biology

Systematic genetic mapping of necroptosis identifies SLC39A7 as modulator of death receptor trafficking

A. Fauster, M. Rebsamen, K. L. Willmann, A. Cesar-Razquin, E. Girardi, J. W. Bigenzahn, F. Schischlik, S. Scorzoni, M. Bruckner, J. Konecka, K. Hörmann, L. X. Heinz, K. Boztug, G. Superti-Furga

The paper uses genetic screens to identify SLC39A7 as a modulator of necroptosis by affecting TNF receptor trafficking and ER homeostasis.

bioRxiv · Mar 29, 2018Cell Biology