Author

G. De Feudis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:genetic perturbation / CRISPR· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

M. R. Ippolito· 3 shared S. Santaguida· 3 shared U. Ben-David· 3 shared Y. Eliezer· 3 shared A. S. Kadmon· 2 shared E. Reuveni· 2 shared F. Vazquez· 2 shared J. Zerbib· 2 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

M. R. Ippolito

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Human aneuploid cells depend on the RAF/MEK/ERK pathway for overcoming increased DNA damage

J. Zerbib, M. R. Ippolito, Y. Eliezer, G. De Feudis, E. Reuveni, A. S. Kadmon, S. Martin, S. Vigano', G. Leor, J. Berstler, K. Laue, Y. Cohen-Sharir, S. Scorzoni, F. Vazquez, U. Ben-David, S. Santaguida

This study identifies the RAF/MEK/ERK pathway as a critical dependency for aneuploid cells, showing increased pathway activity and sensitivity to its inhibition in aneuploid cancer cells.

bioRxiv · Jan 27, 2023Cancer Biology

Increased RNA and protein degradation is required for counteracting transcriptional burden and proteotoxic stress in human aneuploid cells

M. R. Ippolito, J. Zerbib, Y. Eliezer, E. Reuveni, S. Vigano', G. De Feudis, A. S. Kadmon, I. Vigorito, S. Martin, K. Laue, Y. Cohen-Sharir, S. Scorzoni, F. Vazquez, S. Santaguida, U. Ben-David

This study identifies increased RNA and protein degradation as mechanisms by which aneuploid cells counteract transcriptional burden and proteotoxic stress, revealing potential therapeutic targets.

bioRxiv · Jan 27, 2023Cancer Biology

Short-term molecular consequences of chromosome mis-segregation for genome stability

L. Garribba, G. De Feudis, V. Martis, M. Galli, M. Dumont, Y. Eliezer, R. Wardenaar, M. R. Ippolito, D. R. Iyer, A. E. Tijhuis, D. C. Spierings, M. Schubert, S. Taglietti, C. Soriani, S. Gemble, , S. Santaguida

This study shows that aneuploidy can trigger chromosome instability (CIN) by causing DNA replication stress and continuous CIN, leading to genetically diverse cells with varying proliferation abilities.

bioRxiv · Jun 19, 2022Cell Biology