U. Ben-David

Chromosome 7 to the rescue: overcoming chromosome 10 loss in gliomas

The paper investigates the co-occurrence of chromosome 10 loss and chromosome 7 gain in gliomas, finding functional rescue interactions on chromosome 7 that may compensate for chromosome 10 loss.

CDC20 determines the sensitivity to spindle assembly checkpoint (SAC) inhibitors

The paper identifies CDC20 expression as a determinant of sensitivity to SAC inhibitors, showing that aneuploid cells with high CDC20 levels are more sensitive to these drugs.

Inactivation of p53 drives breast cancer brain metastasis by altering fatty acid metabolism

This study shows that p53 inactivation promotes breast cancer brain metastasis by altering fatty acid metabolism, with implications for therapeutic targeting.

A compendium of Amplification-Related Gain Of Sensitivity (ARGOS) genes in human cancer

The paper identifies ARGOS genes, which are amplified in cancer, have low expression relative to copy number, and are toxic when overexpressed, and validates several as pan-cancer targets.

Machine-learning analysis of factors that shape cancer aneuploidy landscapes reveals an important role for negative selection

This study uses machine learning to analyze cancer aneuploidy patterns, revealing that negative selection significantly shapes these landscapes, with tumor-suppressor gene density predicting gain patterns and oncogene density predicting loss patterns.

Computationally Engineered CRISPR-SpyCas9 High-Fidelity Variants with Improved Specificity and Reduced Non-specific DNA Damage

The paper develops ComPE, a computational method to engineer high-fidelity CRISPR-Cas9 variants with improved specificity and reduced off-target effects.

Human aneuploid cells depend on the RAF/MEK/ERK pathway for overcoming increased DNA damage

This study identifies the RAF/MEK/ERK pathway as a critical dependency for aneuploid cells, showing increased pathway activity and sensitivity to its inhibition in aneuploid cancer cells.

Increased RNA and protein degradation is required for counteracting transcriptional burden and proteotoxic stress in human aneuploid cells

This study identifies increased RNA and protein degradation as mechanisms by which aneuploid cells counteract transcriptional burden and proteotoxic stress, revealing potential therapeutic targets.

Short-term molecular consequences of chromosome mis-segregation for genome stability

This study shows that aneuploidy can trigger chromosome instability (CIN) by causing DNA replication stress and continuous CIN, leading to genetically diverse cells with varying proliferation abilities.

Frequent Aneuploidy in Primary Human T Cells Following CRISPR-Cas9 cleavage

This study finds frequent aneuploidy and chromosomal truncations in CRISPR-Cas9-edited primary human T cells, associated with reduced proliferation and p53 activation.

Whole-genome duplication shapes the aneuploidy landscape of human cancers

This study shows that whole-genome duplication (WGD) alters aneuploidy patterns in human cancers, leading to distinct recurrence and genetic interaction patterns between WGD- and WGD+ tumors.

DNA-based copy number analysis confirms genomic evolution of PDX models

The paper reassesses genomic evolution in PDX models using DNA-based copy number profiles, finding significant genomic divergence between primary tumors and PDXs across passages.

Aneuploidy-driven genome instability triggers resistance to chemotherapy

This study shows that aneuploidy-induced genome instability helps cancer cells resist chemotherapy by enabling survival under drug pressure.

Aneuploid cells activate NF-κB to promote their immune clearance by NK cells

The paper shows aneuploid cells activate NF-κB to promote NK cell-mediated immune clearance, with NF-κB inactivation blocking this process in vitro.

Selective vulnerability of aneuploid human cancer cells to inhibition of the spindle assembly checkpoint

This study identifies aneuploid cancer cells as more vulnerable to spindle assembly checkpoint (SAC) inhibition and explores the underlying mechanisms.

Elevated expression of ACE2 in tumor-adjacent normal tissues of cancer patients

The paper finds elevated ACE2 expression in tumor-adjacent normal tissues of cancer patients, suggesting increased COVID-19 risk may extend beyond those with immune suppression.

Non-oncology drugs are a source of previously unappreciated anti-cancer activity

The paper identifies non-oncology drugs with anti-cancer activity across 578 cancer cell lines using PRISM, finding that many drugs selectively inhibit cancer cells based on molecular features.

Patient-derived xenografts undergo murine-specific tumor evolution

This study shows that PDX tumors acquire new genomic changes over passages, differ from human tumors, and affect drug responses.