Author

I. W. Manfield

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Assay:protein structure· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:plant (other)· 1 Assay:protein sequence· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

A. P. Kalverda· 2 shared A. Zhuravleva· 1 shared B. Chen· 1 shared G. Grey· 1 shared G. S. Thompson· 1 shared J. Prusinska· 1 shared J. R. Lewandowski· 1 shared K.-I. Hayashi· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiophysics

A. P. Kalverda

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2 papers

Recent·Most cited

Molecular chaperone BiP controls activity of the ER stress sensor Ire1 through interactions with its oligomers

S. Dawes, N. Hurst, G. Grey, L. Wieteska, N. V. Wright, I. W. Manfield, M. H. Hussain, A. P. Kalverda, J. R. Lewandowski, B. Chen, A. Zhuravleva

This study shows BiP directly interacts with Ire1 oligomers to regulate its activation, controlling ER stress response by modulating Ire1-LD oligomerization.

bioRxiv · Feb 16, 2024 · PreprintBiophysics

A fuzzy encounter complex precedes formation of the fully-engaged TIR1-Aux/IAA auxin co-receptor system

S. Ramans Harborough, A. P. Kalverda, G. S. Thompson, M. L. Kieffer, M. Kubes, M. Quareshy, V. Uzanova, J. Prusinska, K.-I. Hayashi, R. M. Napier, I. W. Manfield, S. Kepinski

This study investigates the assembly of the TIR1-Aux/IAA auxin co-receptor complex using NMR, revealing a fuzzy encounter complex with auxin-dependent and -independent interactions.

bioRxiv · Sep 25, 2019 · PreprintPlant Biology