Author

L. Wieteska

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 4 Approach:experimental assay· 4 Research Focus:protein folding & dynamics· 2 Assay:protein sequence· 2 Assay:protein structure· 2 Approach:wet-lab / biochemical assay· 2 Approach:biophysical modeling· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

C.-C. Lin· 3 shared J. E. Ladbury· 3 shared K. M. Suen· 3 shared Z. Ahmed· 3 shared A. Kalverda· 1 shared A. P. Kalverda· 1 shared A. Stainthorp· 1 shared A. Zhuravleva· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersCell Biology

C.-C. Lin

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Molecular chaperone BiP controls activity of the ER stress sensor Ire1 through interactions with its oligomers

S. Dawes, N. Hurst, G. Grey, L. Wieteska, N. V. Wright, I. W. Manfield, M. H. Hussain, A. P. Kalverda, J. R. Lewandowski, B. Chen, A. Zhuravleva

This study shows BiP directly interacts with Ire1 oligomers to regulate its activation, controlling ER stress response by modulating Ire1-LD oligomerization.

bioRxiv · Feb 16, 2024 · PreprintBiophysics

Receptor tyrosine kinases regulate signal transduction through a liquid-liquid phase separated state

C.-C. Lin, K. M. Suen, P.-A. Jeffrey, L. Wieteska, A. Stainthorp, C. Seiler, H. Koss, C. Molina-Paris, E. A. Miska, Z. Ahmed, J. E. Ladbury

This study shows that RTKs form liquid-liquid phase-separated states with downstream effectors to enhance signaling fidelity.

Molecular Cell · Mar 1, 2022Peer-reviewedCell Biology

Regulation of kinase activity by combined action of juxtamembrane and C-terminal regions of receptors

C.-C. Lin, L. Wieteska, G. Poncet-Montange, K. M. Suen, S. T. Arold, z. ahmed, J. E. Ladbury

The paper investigates how juxtamembrane and C-terminal regions regulate kinase activity in RTKs, identifying key interactions and mutations linked to disease.

bioRxiv · Oct 1, 2020 · PreprintBiochemistry

Grb2 binding induces phosphorylation-independent activation of Shp2

C.-C. Lin, L. Wieteska, K. M. Suen, A. Kalverda, Z. Ahmed, J. E. Ladbury

This study shows Grb2 binding activates Shp2 independently of phosphorylation, and identifies a peptide that blocks this interaction, reducing Shp2 activity and MAPK signaling.

bioRxiv · Nov 29, 2019Cancer Biology