I. Williams

Solution-phase indexing by kinetic confinement enables rapid, simple, and instrument-free single cell transcriptional profiling

This paper introduces an instrument-free method for single-cell transcriptional profiling using kinetic confinement and bifunctional indexing reagents, enabling rapid and scalable analysis.

MYC and HSF1 Cooperate to Drive PLK1 inhibitor Sensitivity in High Grade Serous Ovarian Cancer

This study identifies HSF1 and MYC co-amplification in ovarian cancer and shows that targeting PLK1 is more effective in these cells, suggesting a potential precision medicine approach.

Attenuated humoral responses in HIV infection after SARS-CoV-2 vaccination are linked to global B cell defects and cellular immune profiles

This study examines humoral and cellular immune responses to SARS-CoV-2 vaccination in HIV-infected individuals, finding reduced antibody responses and B cell dysfunction, but robust T cell responses.

Sustainable reference points for multispecies coral reef fisheries

The paper estimates sustainable reference points for multispecies coral reef fisheries using environmental data and assesses their status, finding that over half of jurisdictions have failed sustainability benchmarks.

AKT1 mediates multiple phosphorylation events that functionally promote HSF1 activation

This study identifies AKT1-mediated phosphorylation events that enhance HSF1 activation, with specific residues critical for trimerization and gene transactivation.

Compact Standalone Platform for Neural Recording with Real-Time Spike Sorting and Data Logging

This paper presents a compact system for real-time neural recording and spike sorting in awake animals, achieving low data bandwidth and long-term operation.