N. Hussain

Molecular characterisation of Streptococcus pyogenes (StrepA) non-invasive isolates during the 2022-23 UK upsurge

This study characterizes non-invasive Streptococcus pyogenes isolates from a 2022-23 UK scarlet fever upsurge, revealing strain diversity and genomic features associated with different infection types.

Long noncoding RNA-mediated epigenetic regulation of auxin-related genes controlling shade avoidance syndrome in Arabidopsis thaliana

This study shows that the lncRNA APOLO regulates auxin-related genes involved in shade avoidance syndrome in Arabidopsis thaliana by modulating chromatin structure and gene expression.

Attenuated humoral responses in HIV infection after SARS-CoV-2 vaccination are linked to global B cell defects and cellular immune profiles

This study examines humoral and cellular immune responses to SARS-CoV-2 vaccination in HIV-infected individuals, finding reduced antibody responses and B cell dysfunction, but robust T cell responses.

Structural insights into the organization and channel properties of human Pannexin isoforms 1 and 3

This study presents cryoEM structures of human pannexin 1 and 3 isoforms, revealing structural differences and how a congenital mutation affects channel properties.

An in vitro assessment of anti-SARS-CoV-2 activity of oral preparations of iodine complexes (RENESSANS)

This study assesses the in vitro anti-SARS-CoV-2 activity of iodine complex oral formulations, finding that higher concentrations show significant inhibition of viral replication and cytopathic effects.

Exportin Crm1 is important for Swi6 nucleocytoplasmic shuttling and MBF transcription activation in Saccharomyces cerevisiae

This study shows that Crm1-mediated nuclear export of Swi6 is essential for its transcriptional activity and cell cycle progression in yeast.

CDK4 as a phytochemical based anticancer drug target

This study identifies mangiferin, a compound from mango trees, as a potential anticancer drug targeting CDK4, which is linked to cancer survival rates and expression patterns in GBM, LGG, and SARC.

Importance of parental genome balance in the generation of novel yet heritable epigenetic and transcriptional states during doubled haploid breeding

The paper identifies imbalanced parental genome contributions as a source of transcriptional and epigenetic variation in doubled haploid plants, revealing a role for epigenetic modification of transposons in generating heritable phenotypic diversity.

Dissection of protonation sites for antibacterial recognition and transport in QacA, a multi-drug efflux transporter.

This study identifies key protonation sites in QacA, a multidrug efflux transporter, revealing their roles in substrate recognition and transport of cationic compounds.