Nicotinamide-N-methyltransferase is essential for SAM and 1-methylnicotinamide homeostasis in the AML12 hepatocyte cell line
M. Yoda, R. Mizuno, I. Yoshihiro, M. Takahashi, T. Bamba, S. Kawaoka
This study investigates the role of NNMT in regulating SAM and MNAM metabolism in AML12 hepatocytes, finding that NNMT is a significant consumer of SAM and critical for MNAM production.
bioRxiv · Sep 25, 2022 · PreprintBiochemistry