IRE1 activity regulates tumour and microenvironment cell lineage states while stratifying localised and metastatic prostate cancer.
Dimitrios Doultsinos, Ingrid Tomljanović, Eleftherios D. Pilalis, Sophia M. Abusamra, Romuald Parmentier, I.E. Bridges, Sandy Figiel, Yanis Zekri, Joanna Hester, Damien A. Leach, Charlotte Lynne Bevan, Alastair D.G. Lamb, Wilbert T. Zwart, Aristotelis A. Chatziioannou, Clémentine Le Magnen, Ian Geoffrey Mills
This paper identifies IRE1 activity as a regulator of prostate cancer cell lineage states and shows its role in predicting prognosis and treatment response across localized and metastatic disease.
bioRxiv · Mar 13, 2025 · PreprintCancer Biology