Dietary lipids, not ketone body metabolites, influence intestinal tumorigenesis in a ketogenic diet
Jessica E.S. Shay, Fangtao Chi, Constantine N. Tzouanas, Johanna ten Hoeve, Kevin J. Williams, Tolga Sever, I.J. Ramirez Fuentes, Ömer H. Yilmaz
This study shows that dietary lipids, not ketone body metabolites, drive intestinal tumorigenesis in ketogenic diets, highlighting the role of fatty acid oxidation.
bioRxiv · Jun 6, 2025 · PreprintCancer Biology