Fangtao Chi

The paper shows chronic metabolic stress in liver cells drives developmental programs and functional loss, mirroring tumor states and predicting poor cancer survival.

This study shows that dietary cysteine improves intestinal stem cell repair through IL-22 from CD8+ T cells.

This study shows that PPARγ downregulation in colonic CD8+ T cells of people with HIV on ART leads to epithelial barrier disruption by promoting lipid uptake and apoptosis.

The paper identifies sideroflexins as mitochondrial transporters for neutral amino acids and shows functional overlap among paralogues.

This study shows that dietary lipids, not ketone body metabolites, drive intestinal tumorigenesis in ketogenic diets, highlighting the role of fatty acid oxidation.

The paper identifies intermediate progenitor cells in Drosophila using a split-GAL4 construct and shows they regulate cell fate through Notch signaling and the Ras pathway.

This study investigates how metabolic plasticity drives mammalian embryogenesis by analyzing metabolic shifts during preimplantation stages in mouse embryos.

The paper identifies glucose metabolism as a key regulator of trophectoderm (TE) fate over inner cell mass (ICM) during early mouse embryogenesis through specific metabolic pathways and transcriptional complexes.