Author

Jessica E.S. Shay

Harvard UniversityORCID 0000-0001-7799-1349Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:differential expression· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Fangtao ChiiD· 3 shared Ömer H. YilmaziD· 3 shared Constantine N. TzouanasiD· 2 shared Johanna ten HoeveiD· 2 shared Adam J. RubiniD· 1 shared Alex K. ShalekiD· 1 shared Benjamin E. MeadiD· 1 shared Brandon M. LehrichiD· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersSystems Biology

Fangtao ChiORCID

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3 papers

Recent·Most cited

Systems BiologyCellPeer-reviewedDec 22, 2025

Chronic metabolic stress drives developmental programs and loss of tissue functions in non-transformed liver that mirror tumor states and stratify survival

Constantine N. Tzouanas, Jessica E.S. Shay, Marc Samuel Sherman…·Alex K. Shalek

The paper shows chronic metabolic stress in liver cells drives developmental programs and functional loss, mirroring tumor states and predicting poor cancer survival.

23 citationstop 1%

mousehuman

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Cell BiologyNaturePeer-reviewedOct 1, 2025

Dietary cysteine enhances intestinal stemness via CD8+ T cell-derived IL-22

Fangtao Chi, Qiming Zhang, Jessica E.S. Shay…·Ömer H. Yilmaz

This study shows that dietary cysteine improves intestinal stem cell repair through IL-22 from CD8+ T cells.

21 citationstop 1%

mouseexperimental assay

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Cancer BiologybioRxivPreprintJun 6, 2025

Dietary lipids, not ketone body metabolites, influence intestinal tumorigenesis in a ketogenic diet

Jessica E.S. Shay, Fangtao Chi, Constantine N. Tzouanas…·Ömer H. Yilmaz

This study shows that dietary lipids, not ketone body metabolites, drive intestinal tumorigenesis in ketogenic diets, highlighting the role of fatty acid oxidation.

2 citations

mouseexperimental assay

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