Dimer opening enables brain-type creatine kinase to sense membrane curvature
Samantha L. Gies, Nolan McLaughlin, Orianna H. Kou, Ahmed Shubbar, Chen Kong, Tianqi Wu, Sana Khan, Alessandro Ustione, Ian Miller, David W. Piston, Mahmoud Moradi, Michael L. Gross, Wade F. Zeno, Reza Dastvan
This study identifies dimer opening in CK-BB as a mechanism for sensing membrane curvature and regulating ATP regeneration under acidic conditions and substrate binding.
bioRxiv · Sep 22, 2026 · PreprintBiophysics