Author

Samantha L. Gies

Saint Louis UniversityORCID 0000-0002-7298-4729Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Approach:biophysical modeling· 1 Approach:experimental assay· 1

Frequent Co-Authors

Ian Miller· 2 shared Reza DastvaniD· 2 shared Tianqi WuiD· 2 shared Ahmed Shubbar· 1 shared Alessandro UstioneiD· 1 shared Chen Kong· 1 shared David W. PistoniD· 1 shared Kevin L. JagessariD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersBiophysics

Ian Miller

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2 papers

Recent·Most cited

BiophysicsbioRxivPreprintSep 22, 2026

Dimer opening enables brain-type creatine kinase to sense membrane curvature

Samantha L. Gies, Nolan McLaughlin, Orianna H. Kou…·Reza Dastvan

This study identifies dimer opening in CK-BB as a mechanism for sensing membrane curvature and regulating ATP regeneration under acidic conditions and substrate binding.

DOI 10.64898/2026.08.04.742861

experimental assay

𝕏 PostBluesky

BiophysicsbioRxivPreprintJul 6, 2026

Proton-coupled alternating access in a versatile mycobacterial Spns drug transporter

Kevin L. Jagessar, Samantha L. Gies, Tianqi Wu…·Reza Dastvan

The paper investigates the mechanism of proton-coupled transport in the mycobacterial Spns transporter using spectroscopy, modeling, and mutagenesis, revealing how protonation and substrate binding influence conformational states and transport directionality.

DOI 10.64898/2026.05.09.724020

biophysical modeling

𝕏 PostBluesky