David W. Piston

This study identifies CXCL-CXCR2 signaling as critical for SCLC liver metastasis by enhancing cancer cell migration and interactions with endothelial cells.

This study identifies dimer opening in CK-BB as a mechanism for sensing membrane curvature and regulating ATP regeneration under acidic conditions and substrate binding.

This study identifies a link between circadian temperature compensation and metabolic redox signaling, showing that metabolic sensing modulates the core circadian mechanism to maintain period stability across temperatures.

This study shows that inflammaging in aged tissues drives the development of age-associated CD8+ T cells through adipose tissue niches.

The paper examines mitochondrial positioning in pancreatic beta cells under glucose stimulation and identifies active transport and calcium activity as key regulators of mitochondrial redistribution.

This study shows that Complexin 2 inhibits glucagon and somatostatin secretion and disrupts paracrine inhibition of insulin secretion in pancreatic islets.

This study uses quantum sensors to show that mitochondria in mouse cells regulate temperature and magnetic fields through iron-dependent feedback loops, with altered profiles in a Leigh syndrome model.

This study investigates the role of mu-opioid receptors in pancreatic islet alpha cells, showing they regulate glucagon secretion and are linked to metabolic disease.

This paper identifies a brown adipose tissue-secreted protein fraction that improves glycemia in T1D mice independently of insulin, with nidogen-2 as a key component that inhibits glucagon secretion.

This study identifies Neuroplastin as a binding partner of MANF in pancreatic beta cells, showing it regulates insulin secretion, proliferation, and inflammation, with MANF counteracting these effects.

The paper shows that a short translational ramp in mRNA's first 5 codons significantly affects protein synthesis efficiency, independent of tRNA abundance or initiation efficiency.