Alessandro Ustione

Dimer opening enables brain-type creatine kinase to sense membrane curvature

This study identifies dimer opening in CK-BB as a mechanism for sensing membrane curvature and regulating ATP regeneration under acidic conditions and substrate binding.

Circadian temperature compensation is intrinsically linked with metabolism and redox signaling

This study identifies a link between circadian temperature compensation and metabolic redox signaling, showing that metabolic sensing modulates the core circadian mechanism to maintain period stability across temperatures.

Insulin-Independent Regulation of Type 1 Diabetes via Brown Adipocyte-Secreted Proteins and the Novel Glucagon Regulator Nidogen-2.

This paper identifies a brown adipose tissue-secreted protein fraction that improves glycemia in T1D mice independently of insulin, with nidogen-2 as a key component that inhibits glucagon secretion.

Dual Role of Neuroplastin in Pancreatic Beta Cells: Regulating Insulin Secretion and Promoting Islet Inflammation

This study identifies Neuroplastin as a binding partner of MANF in pancreatic beta cells, showing it regulates insulin secretion, proliferation, and inflammation, with MANF counteracting these effects.