Microtubule detyrosination enhances matrix remodeling and force transmission during endothelial sprouting
Danahé Mohammed, Ibrahim Hamid, Sarah Katharina Steffens, Charlotte Lemeslier, Valérie Martinelli, Apeksha Shapeti, Hans Van Oosterwyck, Benoît Vanhollebeke, Sylvain Gabriele, Maud Martin
This study shows that microtubule detyrosination promotes directional migration and matrix remodeling during endothelial sprouting by enhancing ECM degradation and force transmission.
bioRxiv · Jan 7, 2026 · PreprintCell Biology