Hans Van Oosterwyck

Endothelial gain of PIEZO/TRPV mechanosensors drives cavernous malformations

This study identifies PIEZO1, TRPV2, and TRPV4 as mechanosensors overexpressed in CCM lesions, showing their role in driving disease through altered adhesion and matrix degradation.

Matrix stiffness shifts the endothelial shear stress set point for angiogenic activation

This paper investigates how matrix stiffness and shear stress jointly influence endothelial gene expression and angiogenic activation thresholds using transcriptomics.

Linking Molecular Tension and Cellular Tractions: A Multiscale Approach to Focal Adhesion Mechanics

This study combines Traction Force Microscopy and Vinculin Tension Sensors to analyze how molecular tension and cellular tractions interact across different scales in focal adhesions.

Microtubule detyrosination enhances matrix remodeling and force transmission during endothelial sprouting

This study shows that microtubule detyrosination promotes directional migration and matrix remodeling during endothelial sprouting by enhancing ECM degradation and force transmission.

Osteoarthritic chondrocytes exert higher contractile forces and exhibit enhanced protrusive activity when cultured in 3D degradable hydrogels

This study shows OA chondrocytes generate higher contractile forces in 3D degradable hydrogels compared to 2D, linked to increased protrusive activity and actomyosin engagement.

Data-driven traction force microscopy in 3D collagen hydrogels

This paper introduces DD-TFM, a data-driven 3D traction force microscopy method that models collagen hydrogels as discrete fiber networks, revealing fiber-level matrix deformations caused by endothelial cells.

Adaptation of endothelial cells to microenvironment topographical cues through lysyl oxidase like-2-mediated basement membrane scaffolding

This study shows LOXL2 mediates BM assembly in response to microenvironment topography, affecting endothelial cell behavior and barrier properties.

Inverse modeling of heterogeneous ECM mechanical properties in nonlinear 3DTFM

This paper introduces an inverse methodology for 3DTFM to reconstruct spatially heterogeneous ECM stiffness distributions, validated using in silico cases and compared to L-BFGS.

Simulating flow induced migration in vascular remodelling

The paper develops a computational model of endothelial cell migration during vascular remodelling, showing shear stress and cell elongation are key factors.