Sylvain Gabriele

CurvoChip enables programmable curvature changes on epithelial monolayers to study mechanobiological responses, revealing curvature orientation's impact on cell and nuclear morphology.

This study shows that geometric confinement affects ERK signaling and collective migration in epithelial tissues by altering mechanical states through actomyosin contractility.

This study shows sea stars adjust tube foot adhesion time based on body load and orientation to adapt locomotion without a central nervous system.

This study shows that microtubule detyrosination promotes directional migration and matrix remodeling during endothelial sprouting by enhancing ECM degradation and force transmission.

HYDRA is an automated method for creating hydrogel layers in HTS plates to improve drug testing by mimicking physiological conditions and avoiding meniscus formation.

This study shows electric fields modulate keratocyte migration speed and alignment without changing turning dynamics.

This study shows migrating cells retain a mechanical memory of past morphological states through actin cortex remodeling, aiding navigation in confined spaces.

This study identifies carotenoid-rich coelomocytes in sea cucumbers, challenging the assumption that hemocytes contain haemoglobin and proposing a new classification as carotenocytes.

This study investigates how matrix viscoelasticity and spatial confinement influence epithelial cell mechanobiology and migration on soft and stiff substrates, revealing distinct effects on cell behavior.

This study shows that D-chiral collagen-mimetic peptides reduce cell spreading and adhesion by destabilizing integrin interactions, highlighting the role of ECM chirality in cell migration.