Apeksha Shapeti

This study identifies PIEZO1, TRPV2, and TRPV4 as mechanosensors overexpressed in CCM lesions, showing their role in driving disease through altered adhesion and matrix degradation.

This study shows that microtubule detyrosination promotes directional migration and matrix remodeling during endothelial sprouting by enhancing ECM degradation and force transmission.

This study shows OA chondrocytes generate higher contractile forces in 3D degradable hydrogels compared to 2D, linked to increased protrusive activity and actomyosin engagement.

This paper introduces DD-TFM, a data-driven 3D traction force microscopy method that models collagen hydrogels as discrete fiber networks, revealing fiber-level matrix deformations caused by endothelial cells.

This study shows LOXL2 mediates BM assembly in response to microenvironment topography, affecting endothelial cell behavior and barrier properties.