Author

Idir Malki

Centre National de la Recherche Scientifique

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Adam P. LightfootiD· 1 shared Adrien HerlédaniD· 1 shared Alessia LasorsaiD· 1 shared Amandine Flaig· 1 shared Anaïs-Camille Vreulx· 1 shared Andrew M. FryiD· 1 shared Andrew R. BottrilliD· 1 shared Benoit P. DepreziD· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperMolecular Biology

Adam P. LightfootORCID

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2 papers

Recent·Most cited

Cdk1-mediated threonine phosphorylation of Sam68 modulates its RNA binding, alternative splicing activity, and cellular functions

Idir Malki, Inara Liepina, Nora Kogelnik, Hollie Watmuff, Sue Robinson, Adam P. Lightfoot, Oksana Gonchar, Andrew R. Bottrill, Andrew M. Fry, Cyril Dominguez

This study identifies Cdk1-mediated phosphorylation of Sam68 at T33 and T317, showing it reduces RNA binding and alternative splicing activity, promoting cell proliferation and inhibiting apoptosis in HCT116 cells.

Nucleic Acids Research · Nov 28, 2022Peer-reviewedMolecular Biology

BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr348 phosphorylation

Maxime Sartori, Tiago Mendes, Shruti Desai, Alessia Lasorsa, Adrien Herlédan, Nicolas Malmanche, Petra M. Mäkinen, Mikael Marttinen, Idir Malki, Julien Chapuis, Amandine Flaig, Anaïs-Camille Vreulx, Marion Ciancia, Philippe Amouyel, Florence Leroux, , Jean‐Charles Lambert

This study shows BIN1 overexpression rescues long-term memory deficits in Tau-overexpressing mice and identifies Thr348 phosphorylation as a key regulator of BIN1-Tau interaction.

Acta Neuropathologica · May 7, 2019Peer-reviewedNeuroscience